I've been using the Celtic Cross mostly, but I found an interesting one called The Sacred Quest Spread in Rachel Pollack's book Complete Illustrated Guide to the Tarot.

1. What is your quest?
2. What path are you on?
3. Where does it lead?
4. What opposes you?
5. What aids you?
6. What must you sacrifice?
7. What will you become?

1. Strength
2. King of Coins
3. Four of Swords
4. The Star
5. Ace of Batons
6. Six of Swords
7. Three of Swords

Those darn Swords again.